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| "This historic moment comes at a time of great uncertainty for many Americans. We have now been through nearly a decade of war. We have endured a long and painful recession. And sometimes in the midst of these storms, the future that we are trying to build for our nation - a future of lasting peace and long-term prosperity - may seem beyond our reach" |
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| US President Obama was making a national address Tuesday to mark the end of the combat mission in Iraq |
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Tuscaloosa Times
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Cigarette smoke may cause inflammation through a new chemical pathway
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Cigarette smoke causes a key enzyme that regulates the body's response to inflammation, to shut off, according to a new study.esearchers at University of Alabama at Birmingham found that smoke causes the enzyme to shut down white blood cells following a successful response to inflammation.
The study also found a previously unknown substrate of the enzyme, which recruits white blood cells that attack the cause of the inflammation.
"We found, however, that cigarette smoke inhibited LTA4H, preventing it from shutting down PGP," said J. Edwin Blalock.
Blalock said PGP is a biomarker for several lung diseases that feature chronic inflammation, such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis.
The study also details a dual role played by the enzyme; when contained within a cell, it has a pro-inflammatory job.
However, when the enzyme is found outside of the cell (when the cell it resides in dies, for example) its role switches to an anti-inflammatory one.
"This dual role could have important ramifications for the design of new anti-inflammatory drugs that target LTA4H," said Blalock.
The findings are published online today at Science Express. (ANI) |
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Tuscaloosa Times
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The Tuscaloosa Times is essentially a local Tuscaloosa newspaper, but with a national and international perspective, designed to provide readers with a one-stop shop for Tuscaloosa, national US, regional, and world news coverage, weather and sports information, with live updates on breaking business stories, and what's happening in the financial markets.
The biggest advantage we have is that we are an online newspaper, which means we are constantly refreshing our stories as more and more information comes to hand. Often when a story breaks the initial details are sketchy.
We and our sources around the world work hard to gather more information, verify facts, and provide a perspective of the major stories. Expert opinion often accompanies our articles to better inform readers, and provide a more complete understanding
of the news we deliver.
Financial markets and business reports are regular features as we pin down what's happening, and constantly refresh stock market indice readings, dollar currency rates, and breaking business news reports. Our world sports coverage is a priority, as is our regional news.
We like to think if you're looking for breaking news out of Tuscaloosa, Alabama, the United States, or the world, you'll look for it first at the Tuscaloosa Times. |
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| Metro Hotel on Pitt |
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A truly affordable hotel in Sydney, with stylish decor, great location and in-house snazzy brasserie?
If the notion of...
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